• Special Presidential Envoy for Climate John F. Lerry – sworn in January 20th; new Cabinet-level position.
• Director of National Intelligence Avril Haines – The first woman in charge of the nearly two-decade old agency; confirmed January 20th by an 84 to 10 vote.
• Secretary of Defense Gen. Lloyd T. Austin – The first Black leader of the Pentagon; confirmed January 22nd by a 93 to 2 vote.
• Secretary of Treasury Janet Yellen – The first woman to hold this position; confirmed January 25th by an 84 to 15 vote.
• Secretary of State Antony Blinken – confirmed January 26th by a 78 to 22 vote.
• Transportation Secretary Pete Buttigieg – first openly gay person to be confirmed to hold a Cabinet position; at age 39, one of the youngest ever; confirmed February 2nd by a vote of 86 to 13.
• Secretary of the Department of Homeland Security Alejandro Mayorkas – first Latino and first immigrant to hold the top job at DHS; confirmed February 2nd by a 56 to 43 vote.
• Secretary of Veterans Affairs Denis McDonough – confirmed February 8th by an 87 to 7 vote.
• United States Ambassador to the United Nations Linda Thomas-Greenfield – confirmed February 23rd by a 78 to 20 vote.
• Secretary of Agriculture Tom Vilsack – confirmed February 23rd by a 92 to 7 vote.
• Energy Secretary Jennifer Granholm – confirmed February 25th by a 64-35 vote.
• Secretary of Education Miguel Cardona – confirmed March 1st by a 64 to 33 vote.
• Commerce Secretary Gina M. Raimondo – confirmed March 2nd by a 85 to 15 vote.
• Chair of the Council of Economic Advisers Cecilia Rouse – first Black leader of the CEA; confirmed March 2nd by a 95 to 4 vote .
• Secretary of Housing and Urban Development Marcia Fudge – confirmed March 10th by a 66 to 34 vote.
• U.S. Attorney General Merrick Garland – confirmed March 10th by a 70 to 30 vote.
• Environmental Protection Agency Administrator Michael Regan – first Black man to head agency; confirmed March 10th by a 66 to 34 vote.
• Secretary of Interior Deb Haaland – first Native American Cabinet secretary; confirmed March 15th by a 51 to 40 vote.
• Small Business Administration Isabel Guzman – confirmed March 16th by an 81 to 17 vote.
• United States Trade Representative Katherine Tai – first Asian American and first woman of color to hold this position; confirmed March 17th by a 98 to 0 vote.
• Secretary of Health and Human Services Xavier Becerra – first Latino to head HHS; confirmed March 18th by a 50 to 49 vote.
• CIA Director William J. Burns – marking the first time in decades that a former diplomat will lead the agency; on March 18th, Senators approved his nomination by voice vote.
• Secretary of Labor Marty Walsh –  the first Union leader to run the department in over four decades; confirmed March 22nd by a 68-29 vote.

Withdrawn Nominated Cabinet Member:

• Director of the Office of Management and Budget Neera Tanden – withdrawn on March 2, 2021; reason: Senator Joe Manchin (D-KY) didn’t like mean tweets and views on social media.